Home > About Us > Our background > Engineering and exploiting the stem cell niche > Niche Hub News > Identification of RSPO–LGR4/5–ZNRF3/RNF43 module as a master regulator of Wnt/Beta-catenin-mediated metabolic liver zonation.

28 April 2016

A paper in Nature Cell Biology co-authored by Niche Hub Director Stuart Forbes highlights the RSPO-LGR4/5-ZNRF3/RNF43 module as a master regulator of Wnt/beta-catenin-mediated metabolic liver zonation and as a growth/size control rheostat during liver development, homeostasis and regeneration. The growth-promoting effect of ectopic RSPO1 in livers highlights its potential use for regenerative therapies.

http://www.nature.com/ncb/journal/vaop/ncurrent/pdf/ncb3337.pdf

http://www.ncbi.nlm.nih.gov/pubmed/27088858