Cell behaviour, differentiation and manufacturing

Director: Professor Peter Andrews, University of Sheffield

The key focus of this Hub is to lay foundations for a generic translational pipeline from the derivation of clinical grade pluripotent stem cells to potential cell therapies. The Hub will build upon emerging technologies to optimise processes for consistent, scalable stem cell manufacturing that minimize the appearance of genetic and epigenetic variants, and meet the requirements of clinicians, regulatory authorities and industry for safe and cost-effective applications.  More.. 


Engineering and exploiting the stem cell niche

Director: Professor Stuart Forbes, University of Edinburgh

The key focus of this Hub is to exploit therapeutically our understanding of the biology of stem niches.  The niche (“the soil”) that surrounds stem/progenitor cells (“the seed”) in developing or damaged organs has a profound effect upon the stem/progenitor cells.  We will use this knowledge to optimise the growth and differentiation of stem cells and improve organ regeneration through endogenous repair and cell transplantation.  More.. 


Safety and efficacy, focussing on imaging technologies

Director: Professor Kevin Park, University of Liverpool

The key focus of this Hub is to provide a clearer understanding of the potential hazards (and associated risks) with RMTs and to develop new methodologies to assess their risk, so that scientific stakeholders are able to accelerate these new medicines into the human population with full confidence.  More.. 


Acellular (smart material) approaches for therapeutic delivery

Director: Professor Kevin Shakesheff, University of Nottingham

The key focus of this Hub is to develop platform technologies that use materials and drugs to orchestrate cells to regenerate tissue. In regenerative medicine applications, the cells that generate new tissue can either reside within the patient or be administered as a therapy. In both cases there is a need to create an environment in vivo that facilitiates tissue formation. Therapeutic delivery systems build on principles of biomaterials design and drug delivery to create final products in which the efficacy of cell therapies or the mobilisation of the patient’s own stem cells are maximised.  More.. 


Immunomodulation Hub

Director: Professor Fiona M Watt, King’s College London

The key focus of this Hub is to discover how to harness the immune system for improved outcomes in regenerative medicine.  The central goal of regenerative medicine is to replace damaged or diseased tissue. This can potentially be achieved by stimulating endogenous tissue repair or by transplanting autologous or allogeneic cells. No matter which strategy is taken, host immune responses can represent a formidable obstacle to success.  By modulating different aspects of the immune system we intend to improve the efficacy of regenerative medicine therapies.  More..