Please refer to the links to view our publication outputs to date:
2018
Imaging-Based Screen Identifies Laminin 411 as a Physiologically Relevant Niche Factor with Importance for i-Hep Applications. Ong J et al. Stem Cell Reports. 2018 Mar 13;10(3):693-702. doi: 10.1016/j.stemcr.2018.01.025. Epub 2018 Mar 1.
Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Gillies D et al. Methods. 2018 Mar 1;136:126-133. doi: 10.1016/j.ymeth.2017.10.010. Epub 2017 Oct 31.
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration. Ferreira-Gonzalez S. et al. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5.
Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow. Massam-Wu T et al. Methods Mol Biol. 2018; 1722: 249-560. doi:10.1007/978-1-4939-7553-2_16.
2017
Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety. Meseguer-Ripolles J et al. AAPS J. 2017: 20(1), 20. doi: 10.1208/s12248-017-0171-8. Epub 2017 Dec 21.
Recombinant Extracellular Matrix Protein fragments Support Human Embryonic Stem Cell Chondrogenesis. Cheng A et al. Tissue Eng Part A. doi: 10.1089/ten.TEA.2017.0285. Epub 2017 Dec 27.
The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury. Campana L et al. J. Immunol. 2017. doi:10.4049/jimmunol.1701247. Epub 2017 Dec 20.
Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis. Bergholt M et al. ACS Central Science 2017. doi: 10.1021/acscentsci.7b00367. [Epub ahead of print]
Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. Reinwald Y et al. J Biomed Mater Res A. 2017 Oct 6. doi: 10.1002/jbm.a.36267. [Epub ahead of print]
Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Medina-Rodríguez EM et al. Sci Rep. 2017 Mar 3;7:43545. doi: 10.1038/srep43545.
Liver cell therapy: is this the end of the beginning? Alwahsh SM et al. Cell Mol Life Sci. 2017 Nov 27. doi: 10.1007/s00018-017-2713-8. [Epub ahead of print]
MicroRNA-122 can be measured in capillary blood which facilitates point-of-care testing for drug-induced liver injury. Vliegenthart ADB et al. Br J Clin Pharmacol. 2017 Sep; 83 (9): 2027-2033. doi: 10.1111/bcp.13282. Epub 2017 Apr 5.
Wnt ligand presentation and reception: from the stem cell niche to tissue engineering. Mills KM et al. Open Biol. 2017: 7, 170140. doi:10.1098/rsob.170140 Published online 21 July 2017
Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces. Lowndes, M. et al. Nature Protocols 2017: 12, 1498–1512. doi:10.1038/nprot.2017.061 Published online 29 June 2017
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy. Bergholt MS, Albro MB, Stevens MM. Biomaterials 2017; 140:128-137. doi: 10.1016/j.biomaterials.2017.06.015. Epub 2017 Jun 14.
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration, Raven, A. et al., Nature 2017 July; 547: 350-354. doi:10.1038/nature23015. Epub 2017 July 12.
Raman spectroscopy and regenerative medicine: a review. Ember, K. et al., npj Regenerative Medicine, 2017 May (12) doi:10.1038/s41536-017-0014-3. Epub 2017 May 15
A novel drug induced hybrid electrospun PCL – cell derived ECM scaffold for liver tissue engineering. Grant, R. et al., Tissue Engineering Part A. February 2017, ahead of print. doi:10.1089/ten.TEA.2016.0419.
Quantitative volumetric Raman imaging of three dimensional cell cultures. Kallepitis, C. et al., Nature Comms. 2017 March; 8:14843. doi: 10.1038/ncomms14843. Epub 2017 Mar 22.
Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury. Goldring C et al., Hepatology. 2017 Feb; 65(2): 710-721. doi: 10.1002/hep.28886. Epub 2016 Nov 30.
2016
ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions. Cain, S. A. et al., Sci Rep (2016) 6, 35956.
Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage. Bergholt M. S. et al., ACS Cent. Sci.; 2016 DOI: 10.1021/acscentsci.6b00222. Epub Date: November 16, 2016
Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution. Watt, F. M., Developmental Cell, 2016;38(6), 601-609 doi: http://dx.doi.org/10.1016/j.devcel.2016.08.010
Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. Gieseck, R. L. et al. Immunity 2016; 45(1): 145-158. doi:10.1016/j.immuni.2016.06.009
Quantitative multi-image analysis for biomedical Raman spectroscopic imaging. Hedegaard, M. A. et al. J Biophotonics 2016; 9(5): 542-550. doi:10.1002/jbio.201500238
A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data. Kerz, M. et al. J Biomol Screen 2016; doi:10.1177/1087057116652064
Online monitoring of mechanical properties of three-dimensional tissue engineered constructs for quality assessment. Larin, K. V., et al. Proc. of SPIE 2016; 9710: 971007. doi:10.1117/12.2212320
A high-content platform to characterise human induced pluripotent stem cell lines. Leha, A., et al. Methods 2016; 96: 85-96. doi:10.1016/j.ymeth.2015.11.012
Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering. Lowndes, M., et al. Stem Cell Reports 2016; 7(1): 126-137. doi:10.1016/j.stemcr.2016.06.004
Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering. Lucendo-Villarin, B., et al. J. Mater. Chem. 2016; B 4(20): 3433-3442. doi:10.1039/c6tb00331a
Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells. Parmar, P. A., et al. Biomaterials 2016; 99: 56-71. doi:10.1016/j.biomaterials.2016.05.011
Harnessing the Versatility of Bacterial Collagen to Improve the Chondrogenic Potential of Porous Collagen Scaffolds. Parmar, P. A., et al. Adv Healthc Mater 2016; 5(13): 1656-1666. doi:10.1002/adhm.201600136
The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Planas-Paz, L., et al. Nat Cell Biol 2016; 18(5): 467-479. doi:10.1038/ncb3337
Fluid shear stress modulation of hepatocyte-like cell function. Rashidi, H., et al. Arch Toxicol 2016; 90(7): 1757-1761. doi:10.1007/s00204-016-1689-8
Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells. Reimer, A., et al. Sci Rep 2016; 6: 18948. doi: 10.1038/srep18948
Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine. Szkolnicka, D. and D. C. Hay. Stem Cells 2016; 34(6): 1421-1426. doi: 10.1002/stem.2368
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs. Szkolnicka, D., et al. Stem Cells Transl Med 2016; 5(6): 764-772. doi:10.5966/sctm.2015-0117
Mass production of stem cell derived human hepatocytes for experimental medicine. Wang, Y. and D. C. Hay. Expert Rev Gastroenterol Hepatol 2016; 10(7): 769-771. doi:10.1080/17474124.2016.1182862
CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.Weissman, I. L. and F. M. Watt Cell Stem Cell 2016; 19(1): 19-22. doi:10.1016/j.stem.2016.05.011
Prospective purification of perivascular presumptive mesenchymal stem cells from human adipose tissue: process optimization and cell population metrics across a large cohort of diverse demographics. West, C. C., et al. Stem Cell Res Ther 2016; 7: 47.
2015
Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury.Vliegenthart AD et al., Sci Rep. 2015 Oct 22;5:15501. doi: 10.1038/srep15501.
Recombinant laminins drive the differentiation and self-organisation of hESC-derived hepatocytes. Cameron K, et al., Stem Cell Reports.2015;5(6):1250-62. doi: 10.1016/j.stemcr.2015.10.016.
Protocols in In Vitro Hepatocyte Research. Cameron K, et al., Methods Mol Biol. 2015;1250:v-viii. PMID: 26491729.
CSF1 Restores Innate Immunity Following Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure. Stutchfield BM, et al., Gastroenterology. 2015;149(7):1896-1909.e14. doi: 10.1053/j.gastro.2015.08.053.
CNS Myelin Sheath Lengths Are an Intrinsic Property of Oligodendrocytes. Bechler ME, et al., Current Biology. 2015;25(18):2411-2416. doi:10.1016/j.cub.2015.07.056.
Hepatic progenitor cells of biliary origin with liver repopulation capacity.Lu WL, et al., Nature Cell Biology. 2015;17(8):971-983. doi:10.1038/nbt.3275.
Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor.Rittchen S, et al., Biomaterials. 2015;56:78-85. doi: 10.1016/j.biomaterials.2015.03.044.
Discovery of a new polymer for human pluripotent stem cell expansion and multilineage differentiation. Celiz AD, etal., Adv. Mater.2015;27(27):4006-4012. doi:10.1002/adma.201501351
Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance. Villarin BL, et al., Adv. Healthcare Mater. 2015;140:1798-1803. doi: 10.1002/adhm.201500391.
Stem Cell Heterogeneity and Plasticity in Epithelia. Donati D, et al., Cell Stem Cell. 2015;16(5):465-476. doi:10.1016/j.stem.2015.04.014.
Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells. Godoy P, et al., J. Hepatol. 2015; pii: S0168-8278(15)00340-2. doi:10.1016/j.jhep.2015.05.013.
Cell therapy for liver disease: From liver transplantation to cell factory.Forbes SJ, et al., J Hepatol. 2015;62 (1 Suppl): S157-169. doi:10.1016/j.jhep.2015.02.040.
Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells. Holley RJ, et al., Stem Cell Reports.2015;4(3):473-88. doi:10.1016/j.stemcr.2015.01.007.
The polarity protein scribble regulates myelination and remyelination in the central nervous system. Jarjour AA, et al., PLoS Biol. 2015;13(3):e1002107. doi:10.1371/journal.pbio.1002107.
Most Scottish neurologists do not apply the 2010 McDonald criteria when diagnosing multiple sclerosis. Lumley R, et al., J R Coll Physicians Edinb.2015;45(1):23-6. doi:10.4997/JRCPE.2015.106.
WNT signalling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Boulter L, et al., J. Clin. Invest.2015;125(3):1269-85. doi: 10.1172/JCI76452.
Remyelination in MS: what do we know and where are we going?Williams A. Neurodegenerative Disease Management. 2015;5(1):49-59. doi: 10.2217/nmt.14.40.
High resolution Raman spectroscopy mapping of stem cell micropatterns.von Erlach TC, et al., The Analyst. 2015;140(6):1798-803. doi: 10.1039/c4an02346c.
Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9.Lindner M, et al., Brain 2015;138(Pt 7):1875-93. doi:10.1093/brain/awv102.
2014
Mammalian skin cell biology: at the interface between laboratory and clinic. Watt FM. Science. 2014; 346(6212):937-940. doi:10.1126/science.1253734.
Preparing the ground for tissue regeneration: from mechanism to therapy.Forbes SJ, et al., Nat Med. 2014;20(8):857-869. doi: 10.1038/nm.3653.
Zebrafish regenerate full thickness optic nerve myelin after demyelination, but this fails with increasing age. Münzel E, et al., Acta Neuropathol Commun. 2014;2:77. doi: 10.1186/s40478-014-0077-y.
Stabilizing hepatocellular phenotype using optimized synthetic surfaces. Villarin BL, et al., J Vis Exp. 26;(91):51723. doi:10.3791/51723.
