I am a post-doctoral research fellow currently working at the MRC Centre for Regenerative Medicine (University of Edinburgh). I am a pharmacologist by training having obtained my BSc (Pharmacology, 2008), MRes (Drug Safety, 2009) and PhD (Drug Safety, 2013) at the MRC Centre for Drug Safety Science based at the University of Liverpool under the supervision of Prof. Kevin Park and Dr. Chris Goldring. My research focussed on biomarker qualification and novel ex vivo models of drug-induced liver injury.
In May 2014, I moved to the Centre for Regenerative Medicine to start a new challenge for the safety assessment of regenerative medicine therapies on liver tissue under the supervision of Prof. Stuart Forbes. This work comprises part of the Safety Hub of the UK Regenerative Medicines Platform. My current research interests include the determination of adverse reactions of various regenerative medicine therapies, including stem cells, macrophages and macrophage stimulating agents.
Publications
Hornby R, Starkey Lewis PJ, Antoine DJ, Goldring CE, Park BK. MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans. Expert Review of Clinical Pharmacology 2014; 7 (3): 349-362
Vliegenthart A, Starkey Lewis PJ, Tucker C, Del Pozo J, Rider S, Antoine DJ, Dubost V, et al. Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity. Zebrafish 2014; ahead of print. doi:10.1089/zeb.2013.0912.
Antoine DJ, Dear J, Starkey Lewis PJ*, Platt V, Coyle J, Masson M, Thanacoody R, et al. Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced liver injury at first presentation to hospital. Hepatology 2013; 58(2):777-87.
Antoine DJ, Starkey Lewis PJ, Goldring CE, & Park BK. Are we closer to finding biomarkers for identifying acute drug-induced liver injury? Biomarkers in Medicine 2013; 7 (3): 383-386
Pellegrini G, Starkey Lewis PJ, Palmer L, Hetzel U, Goldring CE, Park BK, Kipar A, Williams DP. Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers. Toxicology 2013; 314(2-3):262-6
Starkey Lewis PJ, Merz M, Couttet P, Grenet O, Dear J, Antoine DJ, Goldring CE, Park BK, Moggs JG. Serum microRNA biomarkers for drug-induced liver injury. Clinical Pharmacology & Therapeutics 2012;92 (3): 291-293
Starkey Lewis PJ, Dear J, Platt V, Moggs J, Goldring C, Park BK. Reply. Hepatology 2012; 55(5): 1642-1643
Starkey Lewis PJ, Dear J, Platt V, Simpson KJ, Craig DG, Antoine DJ, French NS, et al. Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 2011; 54(5): 1767-1776
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