I am a cell biologist with a focus on molecular imaging. I completed my B.Sc. in Cell Biology at the University of Durham in 2009, and completed my PhD at the University of Cambridge in 2013, working on the development of novel genetic reporters for MRI, SPECT, and Bioluminescence imaging.
I am now a research associate at the Centre for Advanced Biomedical Imaging (CABI) at UCL, working on developing in vivo cell tracking techniques for use in stem cells. Particularly, we will focus on techniques for labelling stem cells with genetic reporters, which will allow their survival, differentiation, and biodistribution to be assessed in a model of liver disease, using non-invasive imaging techniques such as SPECT (single photon emission computed tomography), Photo-acoustic imaging, and MRI (Magnetic Resonance Imaging). The goal of this work is to assess the safety, and aid the clinical translation, of stem cell transplantation therapy for liver disease.
Publications:
Oatp1 Enhances Bioluminescence by Acting as a Plasma Membrane Transporter for D-luciferin. Patrick PS, Lyons SK, Rodrigues TB, Brindle KM. Mol Imaging Biol. 2014 May 6. [Epub ahead of print]
Detection of transgene expression using hyperpolarized 13 C urea and diffusion-weighted magnetic resonance spectroscopy. Patrick PS, Kettunen MI, Tee SS, Rodrigues TB, Serrao E, Timm KN, McGuire S, Brindle KM. Magn Reson Med. 2014 Apr 14. doi: 10.1002/mrm.25254. [Epub ahead of print]
Dual-modality gene reporter for in vivo imaging. Patrick PS, Hammersley J, Loizou L, Kettunen MI, Rodrigues TB, Hu DE, Tee SS, Hesketh R, Lyons SK, Soloviev D, Lewis DY, Aime S, Fulton SM, Brindle KM. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):415-20. doi: 10.1073/pnas.1319000111. Epub 2013 Dec 17.
Imaging mouse cancer models in vivo using reporter transgenes. Lyons SK, Patrick PS, Brindle KM. Cold Spring Harb Protoc. 2013 Aug 1;2013(8):685-99. doi: 10.1101/pdb.top069864.
Funded by
