Following my post-doctoral and research fellow work at the Institute of Radiobiology, the Academy of Sciences in Minsk (Belarus) I joined the Centre for Imaging Sciences at the University of Manchester in 2003. This research was focused on the development and application of MR imaging biomarkers in oncology and neuroscience to study the vascular properties of an experimental tumour, tissue oxygenation and to monitor anti-angiogenic antivascular therapies in vivo.
A new non-invasive MR method of quantifying the hypoxic regions of tissus was developed and applied in a human glioblastoma xenograft and in a group of patients with glioblastoma multiform during my work at the Imaging, Translational Sciences (AstraZeneca, UK).
In October 2014 I joined the UKRMP Safety Hub as a Research Associate in a group led by Prof Steve Williams at the Centre for Imaging Sciences at the University of Manchester to undertake imaging studies to track stem cells in the renal disease model and to evaluate their effect on renal function and morphology using MRI and PET.
Relevant Publications:
Inna Linnik, Marietta L J Scott, Katherine F Holliday, Neil Woodhouse, John C Waterton, James P B O’Connor, Hervé Barjat, Carsten Liess, Jose Ulloa, Helen Young, Caroline Dive, Cassandra L Hodgkinson, Tim Ward, Darren Roberts, Samantha J Mills, Gerard Thompson, Giovanni A Buonaccorsi, Susan Cheung, Alan Jackson, Josephine H Naish, Geoff J M Parker. Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma. Magnetic Resonance in Medicine 2014 May;71(5):1854-62.
Linnik I.V., Williams S.R., Davies K.E., McGown A.T., John A. Hadfield J.A, Buckley D.L. Quantitative DCE-MRI as a Screening Tool in the Pre-Clinical Development of Anti-Vascular Drugs. Int. J. of Medical Engineering and Informatics 2012 – Vol. 4, No.4 pp. 362 – 372.
Linnik I.V., McKie S., Stark A.J., Luckman S., Seguin L., Mocaer E., Millan M.J., Deakin B., Williams S.R. The novel antidepressant, agomelatine, blocks cerebral 5-HT2C receptors in vivo: a phMRI challenge study in rats. Eur Neuropsychopharmacol 01/2009; 19.
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